Deferiprone

Deferiprone is an iron chelator that exhibits neuroprotective, anti-Alzheimer's, and immunosuppressive activities. In vivo, deferiprone decreases plasma iron and cholesterol levels, phosphorylation of tau protein, and also decreases levels of amyloid-?40, amyloid-?42, and ?-amyloid precursor cleaving enzyme, BACE 1. In vitro, deferiprone decreases the number of proliferating CD4+ T cells, CD8+ T cells, and CD25+ cells, in vivo, deferiprone decreases disease severity of multiple sclerosis. Deferiprone is also cardioprotective, as it reverses iron-overload cardiomyopathy in clinical heart failure.