DDR-TRK-1

Description: DDR-TRK-1, a selective discoid domain receptor 1 (DDR1) inhibitor, exhibits an IC50 value of 9.4 nM and also inhibits the TRK family. Target: Discoidin Domain Receptor (DDR). Smiles: C[C@@H]1C=2C(CN(C1)C=3C=NC=NC3)=CC(C(NC4=CC(=CC(C(F)(F)F)=C4)N5C=NC(C)=C5)=O)=CC2. References: Zhen Wang, et al. Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors. J Med Chem. 2016 Jun 23, 59(12): 5911-5916.