dBRD9

dBRD9 is a proteolysis-targeting chimera (PROTAC) composed of a bromodomain-containing protein 9 (BRD9) inhibitor conjugated to the cereblon (CRBN) inhibitor pomalidomide (Cay-19877) via an alkyl ether linker. It selectively degrades BRD9 over BRD4 and BRD7 at 100 nM and reduces the proliferation of MOLM-13 leukemia cells in a concentration-dependent manner.. SMILES: O=C(NC(CC1)=O)C1N2C(C3=C(C=CC=C3NCCOCCOCCNC(CN(CC4=C(OC)C=C(C5=CN(C)C(C6=C5C=CN=C6)=O)C=C4OC)C)=O)C2=O)=O. InChi Code: InChI=1S/C40H45N7O10/c1-45(21-29-32(54-3)18-24(19-33(29)55-4)28-22-46(2)38(51)27-20-41-11-10-25(27)28)23-35(49)43-13-15-57-17-16-56-14-12-42-30-7-5-6-26-36(30)40(53)47(39(26)52)31-8-9-34(48)44-37(31)50/h5-7,10-11,18-20,22,31,42H,8-9,12-17,21,23H2,1-4H3,(H,43,49)(H,44,48,50). InChi Key: AIOCFZJGGGEWDK-UHFFFAOYSA-N