Dapagliflozin-d5

Dapagliflozin-d5 is intended for use as an internal standard for the quantification of dapagliflozin (Cay-11574) by GC- or LC-MS. Dapagliflozin is an inhibitor of sodium-glucose transporter 2 (SGLT2, IC50s = 1.12 and 3 nM for the human and rat enzymes, respectively). It is selective for SGLT2 over SGLT1 (IC50s = 1,391 and 620 nM for the human and rat enzymes, respectively) and human adipocyte glucose transporter (GLUT) activity at 20 µM. Dapagliflozin (0.1 and 1 mg/kg) increases urinary glucose levels in normal and Zucker diabetic rats. It decreases fasting and fed plasma glucose levels in Zucker diabetic rats when administered at doses of 0.01, 0.1, and 1 mg/kg.Formal Name: (1S)-1,5-anhydro-1-C-[4-chloro-3-[[4-(ethoxy-1,1,2,2,2-d5)phenyl]methyl]phenyl]-D-glucitol. CAS Number: 1204219-80-6. Molecular Formula: C21H20ClD5O6. Formula Weight: 413.9. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. SMILES: ClC(C=CC([C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)=C2)=C2CC3=CC=C(OC([2H])([2H])C([2H])([2H])[2H])C=C3. InChi Code: InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1/i1D3,2D2. InChi Key: JVHXJTBJCFBINQ-CAXKFZQOSA-N.