Dapagliflozin

Dapagliflozin is an inhibitor of sodium-glucose transporter 2 (SGLT2, IC50s = 1.12 and 3 nM for the human and rat enzymes, respectively). It is selective for SGLT2 over SGLT1 (IC50s = 1,391 and 620 nM for the human and rat enzymes, respectively) and human adipocyte glucose transporter (GLUT) activity at 20 µM. Dapagliflozin (0.1 and 1 mg/kg) increases urinary glucose levels in normal and Zucker diabetic rats. It decreases fasting and fed plasma glucose levels in Zucker diabetic rats when administered at doses of 0.01, 0.1, and 1 mg/kg.Formal Name: (1S)-1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol. CAS Number: 461432-26-8. Synonyms: BMS-512148. Molecular Formula: C21H25ClO6. Formula Weight: 408.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 224, 277 nm. SMILES: ClC(C=CC([C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)=C2)=C2CC3=CC=C(OCC)C=C3. InChi Code: InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1. InChi Key: JVHXJTBJCFBINQ-ADAARDCZSA-N.