Danoprevir

Description: Danoprevir (RG7227) is a peptidomimetic inhibitor of the NS3/4A protease(IC50=0.2-3.5 nM) of hepatitis C virus (HCV). Target: HCV Protease, SARS-CoV. Smiles: CC(C)(C)OC(=O)N[C@H]1CCCCC\C=C/[C@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C1=O)OC(=O)N1Cc2cccc(F)c2C1)C(=O)NS(=O)(=O)C1CC1. References: Seiwert SD, et al. Antimicrob Agents Chemother, 2008, 52(12), 4432-4441.