D-NAME (hydrochloride)

N(G)-Nitro-D-arginine methyl ester (D-NAME) is the less active enantiomer of the nitric oxide (NO) synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME, Cay-80210). D-NAME was initially thought to be inactive and was often used as a negative control for L-NAME. Later studies showed that D-NAME (40 mg/kg/day in rats) can have similar but less pronounced effects as L-NAME (40 mg/kg/day in rats) in the cardiovascular system, particularly at long-term timepoints. D-NAME (3-10 µg/mouse) had no effect on nociception in mice assessed using the tail flick test.Formal Name: N5-[imino(nitroamino)methyl]-D-ornithine, methyl ester, monohydrochloride. CAS Number: 50912-92-0. Synonyms: D-NG-Nitroarginine methyl ester, N(G)-Nitro-D-Arginine methyl ester. Molecular Formula: C7H15N5O4 . HCl. Formula Weight: 269.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 210, 269 nm. SMILES: [H]N(/C(N([H])CCC[C@@H](N)C(OC)=O)=N/[H])[N+]([O-])=O.Cl. InChi Code: InChI=1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15,/h5H,2-4,8H2,1H3,(H3,9,10,11),1H. InChi Key: QBNXAGZYLSRPJK-UHFFFAOYSA-N.