D-myo-Inositol-3,4,5-triphosphate (sodium salt)

D-myo-Inositol-1,4,5-triphosphate (Ins(1,4,5)-P3) is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidyl inositol-4,5-biphosphate. Binding of Ins(1,4,5)-P3 to its receptor on the endoplasmic reticulum in opening of the calcium channels and an increase in intracellular calcium. D-myo-Inositol-3,4,5-triphosphate (Ins(3,4,5)-P3) is a structural analog of Ins(1,4,5)-P3 and a member of the inositol phosphate (InsP) cell signaling family of molecules. D-myo Ins(3,4,5)-P3 is 200-fold less potent than D-myo Ins(1,4,5)-P3 at initiating Ca++ release when injected into Xenopus oocytes. Ins(1,4,5)-P3 binds to Type 1, 2, and 3 subtypes of the rat recombinant IP3 receptor with Ki values of less than 25 nM, whereas Ins(3,4,5)-P3 exhibits significantly lower affinity with Ki values of 3-11 µM.Formal Name: D-myo-inositol-3,4,5-tris(hydrogen phosphate), trisodium salt. Synonyms: Ins(3,4,5)-P3, 3,4,5-IP4. Molecular Formula: C6H12O15P3 . 3Na. Formula Weight: 486.0. Purity: >98%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Water: 50 mg/ml. SMILES: O[C@@H]1[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@@H](OP([O-])(O)=O)[C@@H](O)[C@H]1O.[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C6H15O15P3.3Na/c7-1-2(8)4(19-22(10,11)12)6(21-24(16,17)18)5(3(1)9)20-23(13,14)15,,,/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18),,,/q,3*+1/p-3/t1-,2-,3-,4?,5?,6?,,,/m0.../s1. InChi Key: JENABGGDGLKLTB-UIEDNGEDSA-K.