Cytisine

Cytisine is an alkaloid that has been found in C. laburnum. It is a partial agonist of nicotinic acetylcholine receptors (nAChRs) with an EC50 value of approximately 1 µM for increasing current in Xenopus oocytes expressing alpha4beta2 subunit-containing nAChRs. Cytisine (20 nM) inhibits current induced by acetylcholine (Cay-23829) by 50% in Xenopus oocytes expressing alpha4beta2-subunit containing nAChRs. It binds to alpha2beta2, alpha2beta4, alpha3beta2, alpha3beta4, alpha4beta2, and alpha4beta4 nAChR subunits expressed in HEK293 cells with Ki values of 1.1, 5.4, 37, 220, 1.5, and 2.1 nM, respectively. Cytisine (3 mg/kg) reduces increases in the intracranial self-stimulation (ICSS) threshold of rats withdrawing from nicotine self-administration, indicating a decrease in the dysphoric state induced by nicotine withdrawal.Formal Name: (1R,5S)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one. CAS Number: 485-35-8. Synonyms: Baptitoxine, Cytiton, Laburnin, Sophorine, Tsitafat. Molecular Formula: C11H14N2O. Formula Weight: 190.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 5 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 234, 309 nm. SMILES: O=C1N2C[C@]3([H])CNC[C@](C3)([H])C2=CC=C1. InChi Code: InChI=1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2/t8-,9+/m0/s1. InChi Key: ANJTVLIZGCUXLD-DTWKUNHWSA-N.