Cyclo(Phe-Pro)

Cyclo(Phe-Pro) is a bacterial quorum-sensing molecule that has been found in V. cholerae. It enhances ToxR-dependent transcription of leuO, a DNA binding protein, and inhibits virulence factor production in V. cholerae. Cyclo(Phe-Pro) is an inhibitor of the interaction between retinoic acid-inducible gene I (RIG-I) and the ubiquitin ligase TRIM25. It increases the viral load in Huh7 cells infected with hepatitis C virus (HCV) when used at concentrations of 1, 2.5, and 5 mM. Cyclo(Phe-Pro) (50 mg/kg) reduces the expression of IFN-beta induced by poly(I:C) and increases serum HCV titers in animal models of HCV infection.Formal Name: hexahydro-3-(phenylmethyl)-pyrrolo[1,2-a]pyrazine-1,4-dione. CAS Number: 14705-60-3. Synonyms: A-64863, Cyclo(phenylalanylprolyl), cFP. Molecular Formula: C14H16N2O2. Formula Weight: 244.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, Ethanol: 1 mg/ml. SMILES: O=C1NC(CC2=CC=CC=C2)C(N3CCCC13)=O. InChi Code: InChI=1S/C14H16N2O2/c17-13-12-7-4-8-16(12)14(18)11(15-13)9-10-5-2-1-3-6-10/h1-3,5-6,11-12H,4,7-9H2,(H,15,17). InChi Key: QZBUWPVZSXDWSB-UHFFFAOYSA-N. Origin: Synthetic.