CVN293

A K2P13.1/THIK1 channel inhibitor (IC50 = 49 nM), selective for K2P13.1/THIK1 over K2P6.1/TWIK2 and K2P2.1/TREK-1 channels (IC50s = >30,000 nM for both), inhibits NLRP3 inflammasome-mediated IL-1ß production in LPS-stimulated primary neonatal murine microglia (IC50 = 24 nM). Formulation: A solid. InChI: InChI=1S/C14H10FN7O/c15-9-4-1-5-10-12(9)22(7-8-3-2-6-17-19-8)14(18-10)11-13(16)21-23-20-11/h1-6H,7H2,(H2,16,21). InChIKey: ONRXHVJHFORDDI-UHFFFAOYSA-N. SMILES: NC1=NON=C1C2=NC3=CC=CC(F)=C3N2CC4=CC=CN=N4