CUDA

Description: CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the activity of peroxisome proliferator-activated receptor (PPAR) alpha. CUDA may be valuable for the study of cardiovascular diseases. Target: PPAR, Epoxide Hydrolase. Smiles: N(C(NCCCCCCCCC CCC(O)=O)=O)C1CCCCC1. References: Morisseau C, et al. Structural refinement of inhibitors of urea-based soluble epoxide hydrolases. Biochem Pharmacol. 2002 May 1,63(9):1599-608.