CU-CPT4a

CU-CPT4a is a toll-like receptor 3 (TLR3) antagonist (IC50 = 3.44 µM). It is selective for TLR3 over TLR4, TLR2/6, TLR1/2, and TLR7 at 27 µM. CU-CPT4a inhibits dsRNA binding to TLR3 with a Ki value of 2.96 µM in a fluorescence anisotropy assay. It decreases poly(I:C)-induced production of TNF-alpha and IL-1beta in RAW 264.7 cells when used at a concentration of 27 µM.Formal Name: N-[(3-chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-D-phenylalanine. CAS Number: 1279713-77-7. Molecular Formula: C18H13ClFNO3S. Formula Weight: 377.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM. SMILES: FC1=CC=C(C(Cl)=C(C(N[C@H](CC2=CC=CC=C2)C(O)=O)=O)S3)C3=C1. InChi Code: InChI=1S/C18H13ClFNO3S/c19-15-12-7-6-11(20)9-14(12)25-16(15)17(22)21-13(18(23)24)8-10-4-2-1-3-5-10/h1-7,9,13H,8H2,(H,21,22)(H,23,24)/t13-/m1/s1. InChi Key: IAASQMCXDRISAV-CYBMUJFWSA-N.