CTPI-2

Description: CTPI-2 is an inhibitor of mitochondrial citrate carrier SLC25A1 with(KD : 3.5 µM). CTPI-2 inhibits glycolysis, PPARgamma, and its downstream target the glucose transporter GLUT4. CTPI-2 exhibits anti-tumor activity.CTPI-2 halts salient alterations of NASH reverting steatosis, preventing the evolution to steatohepatitis, reducing inflammatory macrophage infiltration in the liver and adipose tissue, and starkly mitigating obesity induced by a high-fat diet. Target: Mitochondrial Metabolism, Others. Smiles: OC(=O)c1ccccc1NS(=O)(=O)c1ccc(Cl)c(c1)[N+]([O-])=O. References: Tan M, et al. Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD/NASH. Cell Death Differ. 2020,27(7):2143-2157.