CTPI-2

CTPI-2 is an inhibitor of the mitochondrial citrate transporter, also known as SLC25A1. It decreases the oxygen consumption rate (OCR) in tumor spheres isolated from patients with non-small cell lung cancer (NSCLC) and inhibits the invasion of lung cancer stem cells in vitro. CTPI-2 (50 µM) acts synergistically with cisplatin (Cay-13119) to reduce the viability of cisplatin-resistant patient-derived NSCLC cells. It reverses increases in body weight, steatosis, and fasting blood glucose levels in a mouse model of high fat diet-induced non-alcoholic fatty liver disease (NAFLD) when administered at a dose of 50 mg/kg.Formal Name: 2-[[(4-chloro-3-nitrophenyl)sulfonyl]amino]-benzoic acid. CAS Number: 68003-38-3. Molecular Formula: C13H9ClN2O6S. Formula Weight: 356.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 2 mg/ml, DMSO: 5 mg/ml. SMILES: O=C(C1=C(NS(=O)(C2=CC=C(C([N+]([O-])=O)=C2)Cl)=O)C=CC=C1)O. InChi Code: InChI=1S/C13H9ClN2O6S/c14-10-6-5-8(7-12(10)16(19)20)23(21,22)15-11-4-2-1-3-9(11)13(17)18/h1-7,15H,(H,17,18). InChi Key: NJTHPOSQGFJTDP-UHFFFAOYSA-N.