CRANAD 2

Description: CRANAD-2 is a difluoroboron-derivatized curcumins as near-infrared probe for in vivo detection of amyloid-beta deposits. Upon interacting with Abeta aggregates, CRANAD-2 undergoes a range of changes, which include a 70-fold fluorescence intensity increase, a 90 nm blue shift (from 805 to 715 nm), and a large increase in quantum yield. Target: Others. Smiles: CN(C)c1ccc(\C=C\C(=O)\C=C(/OB(F)F)\C=C\c2ccc(cc2)N(C)C)cc1. References: Jara-Guajardo P , Cabrera P , Celis F , et al. Gold Nanoparticles Mediate Improved Detection of beta-amyloid Aggregates by Fluorescence[J]. Nanomaterials, 2020, 10(4).