CPPG

Description: CPPG is a potent antagonist of group II/III mGlu receptors. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC50: 2.2 nM) over group II (IC50: 46.2 nM) mGlu receptors in the rat cerebral cortex. Target: Others. Smiles: C(C(O)=O)(N)(C1CC1)C2=CC=C(P(=O)(O)O)C=C2. References: Toms NJ, et al. The effects of (RS)-alpha-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist. Br J Pharmacol. 1996 Nov,119(5):851-4.