CPHPC

CPHPC is an inhibitor of the protein-protein interaction between serum amyloid P (SAP) and amyloid fibrils (IC50 = 0.9 µM). It also crosslinks with pentameric SAP in the plasma to form a decameric complex, which is eliminated via hepatic clearance. As plasma and amyloid deposits of SAP exist in a dynamic equilibrium, CPHPC induces the dissociation of SAP from tissue amyloid deposits, leading to its redistribution into the plasma, where it is eliminated. DPHC (1 mg/ml in the drinking water) reduces serum human SAP levels in a transgenic mouse model of amyloidosis.Formal Name: 1,1'-(1,6-dioxo-1,6-hexanediyl)bis-D-proline. CAS Number: 224624-80-0. Synonyms: GSK2315698, Miridesap, Ro 63-8695. Molecular Formula: C16H24N2O6. Formula Weight: 340.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 20 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O=C(CCCCC(N1CCC[C@@H]1C(O)=O)=O)N2[C@@H](C(O)=O)CCC2. InChi Code: InChI=1S/C16H24N2O6/c19-13(17-9-3-5-11(17)15(21)22)7-1-2-8-14(20)18-10-4-6-12(18)16(23)24/h11-12H,1-10H2,(H,21,22)(H,23,24). InChi Key: HZLAWYIBLZNRFZ-UHFFFAOYSA-N.