Coumarin-3-carboxylic acid

RTECS: DJ2490000 Source/Host Chemicals: Synthetic. Purity Chemicals: >98% (NMR) Appearance: Beige powder. Solubility: Soluble in DMSO. Slightly soluble in water (1mg/ml). Identity: Determined by 1H-NMR. InChi Key: ACMLKANOGIVEPB-UHFFFAOYSA-N Smiles: O=C1OC2=CC=CC=C2C=C1C(O)=O Coumarin-3-carboxylic acid can be used for quantitative, sensitive, specific detection of hydroxyl radicals (.OH) in aqueous solutions. Spectral Data: lambdaex=395nm, lambdaem=450nm. Fluorescence detection of 3-CCA hydroxylation allows real-time measurement of the kinetics of .OH generation (by gamma-irradiation or chemically). Coumarin-3-carboxylic acid is also a building block and intermediate for the synthesis of coumarins which are well known natural products for their diverse biological activities. Product References: [1] Y. Manevich, et al., Radiat. Res. 148, 580 (1997) , [2] B. Thati, et al., Cancer Lett. 248, 321 (2007) , [3] S. Yamashita, et al., Free Radic. Res. 46, 861 (2012) , [4] H. Ji, et al., Bioorg. Med. Chem. 29, 115870 (2021) , [5] S.N. Esfahani, et al., Sci. Rep. 11, 20088 (2021) , [6] Q.Yang, et al., Photochem. Photobiol. Sci. 21, 1481 (2022)