Columbin

Columbin is a diterpenoid furanolactone isolated from J. columba, A. albida, and T. bakis that has diverse biological activities. It inhibits the growth of T. brucei in vitro and induces complete parasite clearance in T. brucei-infected mice when administered at a dose of 25 mg/kg per day for three days. Columbin selectively inhibits COX-2 over COX-1 (EC50s = 53.1 and 327 µM, respectively) and reduces carrageenan-induced paw edema in rats in a dose-dependent manner. Dietary feeding of columbin (4, 20, and 100 ppm) reduces the number of lesions in a rat model of azoxymethane-induced colon carcinogenesis. Columbin (20-40 mg/kg per day) also reduces sleeping time induced by a mixture of urethane and alpha-choralose but prolongs sleeping time induced by hexobarbital in mice.Formal Name: 9-(3-furanyl)-1R,4R,4aR,5,6,6aR,9S,10,10aS,10bS-decahydro-4-hydroxy-4a,10a-dimethyl-1,4-etheno-3H,7H-benzo[1,2-c:3,4-c']dipyran-3,7-dione. CAS Number: 546-97-4. Molecular Formula: C20H22O6. Formula Weight: 358.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 0.03 mg/ml. SMILES: O=C1O[C@H](C2=COC=C2)C[C@]3(C)[C@@]1([H])CC[C@]([C@]4(O)C=C5)(C)[C@@]3([H])[C@]5([H])OC4=O. InChi Code: InChI=1S/C20H22O6/c1-18-9-14(11-5-8-24-10-11)25-16(21)12(18)3-6-19(2)15(18)13-4-7-20(19,23)17(22)26-13/h4-5,7-8,10,12-15,23H,3,6,9H2,1-2H3/t12-,13+,14-,15-,18+,19+,20-/m0/s1. InChi Key: AALLCALQGXXWNA-QJNFORGASA-N.