Columbamine

Columbamine is an alkaloid that has been found in Plumeria rubra and has diverse biological activities. It is also a metabolite of berberine (Cay-10006427). Columbamine inhibits the cytochrome P450 (CYP) isoform CYP3A4 (IC50 = 30.6 µM). It is active against P. falciparum (IC50 = 1.92 µM). It decreases glucose consumption of, and triglyceride levels in, HepG2 cells when used at concentrations of 3 and 15 µM, respectively. Columbamine (56 mg/kg) reduces xylene-induced ear edema and acetic acid-induced writhing in mice.Formal Name: 5,6-dihydro-2-hydroxy-3,9,10-trimethoxy-dibenzo[a,g]quinolizinium. CAS Number: 3621-36-1. Synonyms: Dehydroisocorypalmine. Molecular Formula: C20H20NO4. Formula Weight: 338.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 230, 266, 351 nm. SMILES: OC1=C(OC)C=C2CC[N+]3=C(C=C4C=CC(OC)=C(C4=C3)OC)C2=C1. InChi Code: InChI=1S/C20H19NO4/c1-23-18-5-4-12-8-16-14-10-17(22)19(24-2)9-13(14)6-7-21(16)11-15(12)20(18)25-3/h4-5,8-11H,6-7H2,1-3H3/p+1. InChi Key: YYFOFDHQVIODOQ-UHFFFAOYSA-O. Origin: Plant/Coptis chinensis.