Coenzyme Q2

Coenzyme Q10 (Cay-11506) is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. In its reduced form, it acts as an antioxidant. Coenzyme Q2 (CoQ2) is a biosynthetic precursor to the electron transport chain cofactor CoQ10 (Cay-11506) and an inhibitor of mitochondrial complex I, also known as NADH dehydrogenase. It is an electron acceptor that accepts electrons from mitochondrial complex I. CoQ2 inhibits the proliferation of BALL-1 human B cell acute lymphoblastic leukemia cells (IC50 = 20 µM) and induces apoptosis in Huh7 and HepG2 hepatoma cells when used at a concentration of 100 µM. It increases the production of reactive oxygen species (ROS) in BALL-1 cells but inhibits ROS production in mitochondrial membranes derived from bovine heart when used in combination with the mitochondrial complex I inhibitors rotenone (Cay-13995), piericidin A (Cay-15379), or rolliniastatin 1 or -2. CoQ2 increases the production of hydrogen peroxide in isolated rabbit heart mitochondria and decreases it in isolated rabbit liver mitochondria.Formal Name: 2-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione. CAS Number: 606-06-4. Synonyms: CoQ2, Ubiquinone-2, Ubiquinone Q2. Molecular Formula: C19H26O4. Formula Weight: 318.4. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 10 mg/ml, Ethanol: 10 mg/ml. lambdamax: 274 nm. SMILES: O=C(C(OC)=C1OC)C(C)=C(C/C=C(CC/C=C(C)/C)\C)C1=O. InChi Code: InChI=1S/C19H26O4/c1-12(2)8-7-9-13(3)10-11-15-14(4)16(20)18(22-5)19(23-6)17(15)21/h8,10H,7,9,11H2,1-6H3/b13-10+. InChi Key: SQQWBSBBCSFQGC-JLHYYAGUSA-N.