Coclaurine

Coclaurine is a benzylisoquinoline alkaloid that has been found in T. quinquenervia and has nicotinic acetylcholine receptor (nAChR) inhibitory and insecticidal activities. It inhibits ACh-induced currents in Xenopus oocytes expressing human alpha4beta2 or alpha4beta4 subunit-containing nAChRs (IC50s = 49 and 18 µM, respectively). Coclaurine induces mortality in D. melanogaster and C. pomonella larvae (LD50s = 78.2 and 35.4 µg/ml, respectively).Formal Name: (1S)-1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6-methoxy-7-isoquinolinol. CAS Number: 486-39-5. Synonyms: (S)-Coclaurine, (-)-Coclaurine. Molecular Formula: C17H19NO3. Formula Weight: 285.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetone: soluble, Chloroform: soluble, Dichloromethane: soluble, DMSO: soluble. lambdamax: 227 nm. SMILES: COC(C=C(CCN1)C([C@@H]1CC2=CC=C(C=C2)O)=C3)=C3O. InChi Code: InChI=1S/C17H19NO3/c1-21-17-9-12-6-7-18-15(14(12)10-16(17)20)8-11-2-4-13(19)5-3-11/h2-5,9-10,15,18-20H,6-8H2,1H3/t15-/m0/s1. InChi Key: LVVKXRQZSRUVPY-HNNXBMFYSA-N. Origin: Plant/Lindera aggregata (Sims) Kosterm..