CLM3

Description: CLM3, a pyrazolopyrimidine derivative, functions as a multitargeted tyrosine kinase inhibitor. It exhibits antiproliferative and proapoptotic activities on endothelial and cancer cells, activities that are synergistically enhanced by SN38. The primary mechanism of action for CLM3 involves the inhibition of phosphorylation in tyrosine kinases such as VEGFR-2, EGFR, and RET, along with their associated signaling pathways. Target: Apoptosis, VEGFR, EGFR. Smiles: N([C@H](C)C1=CC=CC=C1)C2=C3C(N(CCC4=CC=CC=C4)N=C3)=NC=N2