CK-869

CK-869 is an inhibitor of actin polymerization via inhibition of the actin-related protein 2/3 (Arp2/3) complex, leading to reduced cell motility rate and rearrangement of F-actin in M-1 cells. It inhibits comet tail formation by L. monocytogenes with an IC50 value of 7 µM. It also impairs cell adhesion and cell spreading in MCF10A human breast epithelial cells.Formal Name: 2-(3-bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone. CAS Number: 388592-44-7. Synonyms: CK-0157869. Molecular Formula: C17H16BrNO3S. Formula Weight: 394.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1.5 mg/ml, DMSO: 2.5 mg/ml, DMSO:PBS (pH 7.2) (1:20): 0.05 mg/ml. lambdamax: 278 nm. SMILES: O=C1N(C2=CC=C(OC)C=C2OC)C(C3=CC=CC(Br)=C3)SC1. InChi Code: InChI=1S/C17H16BrNO3S/c1-21-13-6-7-14(15(9-13)22-2)19-16(20)10-23-17(19)11-4-3-5-12(18)8-11/h3-9,17H,10H2,1-2H3. InChi Key: MVWNPZYLNLATCH-UHFFFAOYSA-N.