CK-666

Description: CK-666 is a cell-permeable inhibitor of the actin-related protein Arp2/3 complex, binding to and stabilizing its inactive state, thereby preventing the movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) configuration. Target: Microtubule Associated, HIV Protease. Smiles: Cc1[nH]c2ccccc2c1CCNC(=O)c1ccccc1F. References: Hetrick B, et al. Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 2013 May 23,20(5):701-12.