cis-ACCP

Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins, thus enabling cell migration. Overexpression of MMPs are linked to diseases such as cancer, arthritis, osteoporosis, and arteriosclerosis. cis-ACCP is a reversible and competitive inhibitor of type IV collagen-specific MMP-2 and MMP-9 with preference towards MMP-2 (IC50 = 4 and 20 µM, respectively). At 100 µM, cis-ACCP prevents 90% of tumor cell invasion across matrigel-coated membranes in vitro.Formal Name: P-[[[(1R,2S)-2-aminocyclohexyl]amino]carbonyl]-phosphonic acid. CAS Number: 777075-44-2. Molecular Formula: C7H15N2O4P. Formula Weight: 222.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Water: 1 mg/ml. SMILES: N[C@H]1CCCC[C@H]1NC(P(O)(O)=O)=O. InChi Code: InChI=1S/C7H15N2O4P/c8-5-3-1-2-4-6(5)9-7(10)14(11,12)13/h5-6H,1-4,8H2,(H,9,10)(H2,11,12,13)/t5-,6+/m0/s1. InChi Key: XHCXISPZIHYKQD-NTSWFWBYSA-N.