Cinnamtannin B-1

Cinnamtannin B-1 is a proanthocyanidin polyphenol originally isolated from cinnamon bark that has antioxidant properties. Cinnamtannin B-1 has antioxidant properties in vitro, including inhibition of lipid peroxidation (IC50 = 2.25 µM). It also protects astrocytes and increases proliferation in an in vitro model of ischemia/reperfusion injury. In mice, it enhances migration of mesenchymal stem cells and improves wound healing. It exhibits COX-2 inhibition with 19, 27, and 86% inhibition in Sf9 cells at 10, 100, and 1,000 µg/ml, respectively.Formal Name: (2R,3R,4S,8S,14R,15R)-2,8-bis(3,4-dihydroxyphenyl)-4-[(2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-3,5,7-trihydroxy-2H-1-benzopyran-8-yl]-3,4-dihydro-8,14-methano-2H,14H-1-benzopyrano[7,8-d][1,3]benzodioxocin-3,5,11,13,15-pentol. CAS Number: 88082-60-4. Synonyms: LDN-0022358. Molecular Formula: C45H36O18. Formula Weight: 864.8. Purity: >85%. Formulation: (Request formulation change), A solid. Solubility: DMSO:Water (1:1): Soluble, Ethanol: Soluble, Methanol: Soluble. SMILES: OC1=CC([C@H]2OC(C([C@@H]3[C@@H](O)[C@@H](C4=CC=C(O)C(O)=C4)OC5=C3C(O)=CC6=C5[C@@H](C(C(O)=CC(O)=C7)=C7O8)[C@](O)([H])[C@]8(C9=CC=C(O)C(O)=C9)O6)=C(O)C=C%10O)=C%10C[C@H]2O)=CC=C1O. InChi Code: InChI=1S/C45H36O18/c46-18-10-27(54)33-31(11-18)62-45(17-3-6-22(49)26(53)9-17)44(59)38(33)36-32(63-45)14-29(56)35-37(39(58)41(61-43(35)36)16-2-5-21(48)25(52)8-16)34-28(55)13-23(50)19-12-30(57)40(60-42(19)34)15-1-4-20(47)24(51)7-15/h1-11,13-14,30,37-41. InChi Key: BYSRPHRKESMCPO-LQNPQWRQSA-N. Origin: Plant/Laurus nobills L..