Cinacalcet (hydrochloride)

Cinacalcet is a calcimimetic and an allosteric agonist of the calcium-sensing receptor (CaSR, EC50 = 79.4 nM in HEK293T cells expressing the human receptor). In vivo, cinacalcet (0.1-10 mg/kg, s.c.) decreases plasma levels of parathyroid hormone (PTH) in rats. It also decreases plasma levels of PTH and parathyroid cell proliferation in a mouse model of primary hyperparathyroidism. Formulations containing cinacalcet have been used in the treatment of secondary hyperparathyroidism due to end-stage renal disease and hypercalcemia in patients with parathyroid carcinoma.Formal Name: alphaR-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine, monohydrochloride. CAS Number: 364782-34-3. Synonyms: AMG 073, KRN 1493, Mimpara. Molecular Formula: C22H22F3N . HCl. Formula Weight: 393.9. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml. lambdamax: 223, 282 nm. SMILES: C[C@@H](NCCCC1=CC(C(F)(F)F)=CC=C1)C2=CC=CC3=C2C=CC=C3.Cl. InChi Code: InChI=1S/C22H22F3N.ClH/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25,/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3,1H/t16-,/m1./s1. InChi Key: QANQWUQOEJZMLL-PKLMIRHRSA-N.