Chroman 1

Chroman 1 is an inhibitor of Rho-associated kinase 2 (ROCK2, IC50 = 50s = 1,740 and 127 nM, respectively). Chroman 1 inhibits the phosphorylation of myosin light-chain (MLC) in a cell-based assay (IC50 = <4 nM).Formal Name: (3S)-N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2H-1-benzopyran-3-carboxamide. CAS Number: 1273579-40-0. Synonyms: (S)-Chroman 1. Molecular Formula: C24H28N4O4. Formula Weight: 436.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. lambdamax: 273, 300 nm. SMILES: CN(C)CCOC(C=C(C1=CNN=C1)C=C2)=C2NC([C@H]3CC4=CC(OC)=CC=C4OC3)=O. InChi Code: InChI=1S/C24H28N4O4/c1-28(2)8-9-31-23-12-16(19-13-25-26-14-19)4-6-21(23)27-24(29)18-10-17-11-20(30-3)5-7-22(17)32-15-18/h4-7,11-14,18H,8-10,15H2,1-3H3,(H,25,26)(H,27,29)/t18-/m0/s1. InChi Key: ROFMCPHQNWGXGE-SFHVURJKSA-N.