Choline-d9 (chloride)

Choline-d9 is intended for use as an internal standard for the quantification of choline (Cay-31178) by GC- or LC-MS. Choline is an essential nutrient with roles in liver, neurological, hematological, and skeletal muscle homeostasis. It is a precursor in the biosynthesis of membrane phospholipids, such as phosphatidylcholine, which facilitate cell signaling and transport across the membrane, and a precursor to the neurotransmitter acetylcholine. Choline is required for hepatic lipid transport. Perinatal administration of choline (18.8 mg/kg) improves prenatal alcohol exposure-induced cognitive deficits in rats. Choline (13 mg/animal per day) improves motor coordination and behavioral deficits in a mouse model of Rett syndrome, as well as improves deficits in recognition memory induced by early-life iron deficiency in rats when administered in the drinking water at a concentration of 5 ppm. Deficiencies in choline intake are positively correlated with muscle wasting, and dietary administration of choline (1,000 mg/kg) increases leg and breast muscle protein content in broiler chickens.Formal Name: 2-hydroxy-N,N,N-tri(methyl-d3)-ethanaminium, monochloride. CAS Number: 61037-86-3. Molecular Formula: C5H5D9NO . Cl. Formula Weight: 148.7. Purity: >99% deuterated forms (d1-d9). Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble, Ethanol: 2 mg/ml, PBS (pH 7.2): 2 mg/ml. SMILES: [2H]C([2H])([2H])[N+](C([2H])([2H])[2H])(C([2H])([2H])[2H])CCO.[Cl-]. InChi Code: InChI=1S/C5H14NO.ClH/c1-6(2,3)4-5-7,/h7H,4-5H2,1-3H3,1H/q+1,/p-1/i1D3,2D3,3D3,. InChi Key: SGMZJAMFUVOLNK-KYRNGWDOSA-M.