Cholesterol

Description: Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor alpha (ERRalpha). Cholesterol is widely found in the cell membranes of animals and is also used in the synthesis of several important hormones and bile acids. Target: MRP, Estrogen Receptor/ERR, ROR, Endogenous Metabolite. Smiles: CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C. References: Sengupta S, et al. Cholesterol-dependent plasma membrane order (Lo) is critical for antigen-specific clonal expansion of CD4+ T cells. Sci Rep. 2021 Jul 7,11(1):13970.