Chlormezanone

Chlormezanone is a centrally acting muscle relaxant. It induces paralysis in mice, guinea pigs, dogs, cats, and monkeys (EC50s = 133, <200, 100-250, 50, and 50 mg/kg, respectively). Chlormezanone increases ataxia induced by pentobarbital and alcohol in mice and blocks the crossed extensor reflex of the spine without affecting the knee-jerk reflex in cats. It also induces head drop in rabbits.Formal Name: 2-(4-chlorophenyl)tetrahydro-3-methyl-4H-1,3-thiazin-4-one, 1,1-dioxide. CAS Number: 80-77-3. Synonyms: (±)-Chlormezanone, NSC 169108. Molecular Formula: C11H12ClNO3S. Formula Weight: 273.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 20 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): 0.1 mg/ml. lambdamax: 228 nm. SMILES: ClC1=CC=C(C2N(C)C(CCS2(=O)=O)=O)C=C1. InChi Code: InChI=1S/C11H12ClNO3S/c1-13-10(14)6-7-17(15,16)11(13)8-2-4-9(12)5-3-8/h2-5,11H,6-7H2,1H3. InChi Key: WEQAYVWKMWHEJO-UHFFFAOYSA-N.