CFM 4

CFM 4 is an inhibitor of the protein-protein interaction between anaphase-promoting complex subunit 2 (APC2) and cell cycle and apoptosis regulatory protein 1 (CARP-1). It inhibits the binding of APC2 to CARP-1 (IC50 = 0.75 µM). CFM 4 reduces the proliferation of a variety of breast, prostate, and colon cancer cells in a concentration-dependent manner. It induces cell cycle arrest at the G0 phase in MDA-MB-468 breast cancer cells and apoptosis in T47D breast cancer cells when used at a concentration of 20 µM. Nanostructure lipid carrier-encapsulated CFM 4 (40 mg/kg every other day) reduces tumor growth in an A549 non-small cell lung cancer (NSCLC) mouse xenograft model.Formal Name: 1-[(2-chlorophenyl)methyl]-5'-phenyl-spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one. CAS Number: 331458-02-7. Molecular Formula: C22H16ClN3OS. Formula Weight: 405.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 25 mg/ml. SMILES: O=C1N(CC2=C(Cl)C=CC=C2)C3=C(C14SC(C5=CC=CC=C5)=NN4)C=CC=C3. InChi Code: InChI=1S/C22H16ClN3OS/c23-18-12-6-4-10-16(18)14-26-19-13-7-5-11-17(19)22(21(26)27)25-24-20(28-22)15-8-2-1-3-9-15/h1-13,25H,14H2. InChi Key: PMADITKBVODKSF-UHFFFAOYSA-N.