Cetrorelix Acetate

Cetrorelix is a gonadotropin-releasing hormone (GnRH) analog that inhibits LHRH and GnRH. Cetrorelix exhibits anti-inflammatory activity and has been used clinically as a treatment for infertility due to its suppression of FSH and LH levels. In animal models of benign prostatic hyperplasia (BPH), cetrorelix decreases levels of inflammatory cytokines and growth factors, decreasing prostate size and weight. Additionally, cetrorelix decreases levels of Bax, caspase 3, and cytochrome c, inhibiting chemotherapy-induced mitochondria-dependent apoptosis in granulosa cells in vivo.