Cercosporin

Cercosporin is a pigmented phytotoxin isolated from the fungus C. kikuchii that produces reactive oxygen species in plant hosts leading to cellular damage. It exhibits light-activated cytotoxic effects in vitro with cytotoxic concentration (CC50) values of 241, 282, and 174 nM in HeLa, A432, and MCF-7 cells, respectively. It is a selective inhibitor of PKC (IC50 = 600-1,300 nM) with no activity on PKA or PPK at concentrations over 180 µM.Formal Name: (13bR)-6,12-dihydroxy-8,9-bis[(2R)-2-hydroxypropyl]-7,10-dimethoxy-perylo[1,12-def]-1,3-dioxepin-5,11-dione. CAS Number: 35082-49-6. Synonyms: CGP 049090, NSC 153111. Molecular Formula: C29H26O10. Formula Weight: 534.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, DMSO: soluble, Ethanol: soluble. lambdamax: 225, 269, 470 nm. SMILES: COC(C1=O)=C(CC(O)C)C2=C3C(C(C(C=C4OCO5)=O)=C(O)C(OC)=C3CC(C)O)=C4C6=C5C=C(O)C1=C26. InChi Code: InChI=1S/C29H26O10/c1-10(30)5-12-18-19-13(6-11(2)31)29(37-4)27(35)21-15(33)8-17-23(25(19)21)22-16(38-9-39-17)7-14(32)20(24(18)22)26(34)28(12)36-3/h7-8,10-11,30-32,35H,5-6,9H2,1-4H3. InChi Key: JWFLIMIGORGZMQ-UHFFFAOYSA-N. Origin: Fungus/Cercospora sp..