Ceforanide

Description: Ceforanide is a second-generation cephalosporin antibiotic with bactericidal activity. Ceforanide causes inhibition of bacterial cell wall synthesis by inactivating penicillin binding proteins (PBPs) thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of the cell wall. Target: Antibacterial, Antibiotic. Smiles: [H][C@]12SCC(CSc3nnnn3CC(O)=O)=C(N1C(=O)[C@H]2NC(=O)Cc1ccccc1CN)C(O)=O. References: Sifakis S, et al. Chemoprophylactic and bactericidal efficacy of 80 mg gentamicin in a single and once-daily dosing. Arch Gynecol Obstet. 2005 Sep,272(3):201-6.