CCCP

Description: CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. CCCP inhibits the activation of STING and its downstream signaling molecules TBK1 and IRF3. Target: Mitochondrial Metabolism, COX, IkappaB/IKK, Apoptosis, IFNAR, Antibacterial, STING. Smiles: ClC1=CC=CC(N\N=C(/C#N)C#N)=C1. References: Padman BS, et al. The protonophore CCCP interferes with lysosomal degradation of autophagic cargo in yeast and mammalian cells. Autophagy. 2013 Nov 1,9(11):1862-75.