CAY10770

CAY10770 is an inhibitor of the cytochrome P450 (CYP) isoform CYP4Z1 (IC50 = 5.9 µM). It is selective for CYP4Z1 over CYP4A11, CYP4F2, CYP4F3a, CYP4F3b (IC50s = 187-282 µM) but does inhibit CYP4F8 and CYP4F12 (IC50s = 167 and 91 µM, respectively). CAY10770 (3 µM) inhibits the production of 14(15)-EET, 19-HETE, and 14(15)-DiHET by 83, 86, and 80%, respectively, in T47D breast cancer cells expressing CYP4Z1.Formal Name: 8-(1H-benzotriazol-1-ylamino)-octanoic acid. CAS Number: 2428734-45-4. Molecular Formula: C14H20N4O2. Formula Weight: 276.3. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: Chloroform: 10 mg/ml, Ethanol: 1 mg/ml, Methyl Acetate: 1 mg/ml. SMILES: OC(CCCCCCCNN1N=NC2=C1C=CC=C2)=O. InChi Code: InChI=1S/C14H20N4O2/c19-14(20)10-4-2-1-3-7-11-15-18-13-9-6-5-8-12(13)16-17-18/h5-6,8-9,15H,1-4,7,10-11H2,(H,19,20). InChi Key: XRQULSHHDALTQA-UHFFFAOYSA-N.