CAY10564

S-Nitrosothiols (RSNOs) are a class of molecules that function as exogenous and endogenous nitric oxide (NO) donors. RSNOs found in vivo include proteins such as S-nitrosohemoglobin and S-nitrosoalbumin, as well as low molecular weight species such as S-nitrosoglutathione (GSNO) and S-nitrosocysteine (CysNO). CAY10564 is a member of a new class of S-nitrosothiol species that act as NO donors under acidic conditions. It decomposes with a half-life of one minute in 0.1 M phosphate buffer, pH 5.0, at 37°C and relaxes phenylephrine-constricted rat aortic strips 59% and 16% at pH 6.0 and 7.4, respectively.Formal Name: 4-(4-chlorophenyl)-4,5-dihydro-1,3,2-oxathiazol-3-ium-5-olate. Synonyms: 4-chloro-4-phenyl-1,3,2-Oxathiazolidine-5-one, 4-(p-chlorophenyl)-1,3,2-Oxathiazolylium-5-olate. Molecular Formula: C8H6ClNO2S. Formula Weight: 215.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:5): 0.25 mg/ml, Ethanol: 1 mg/ml. lambdamax: 202, 262, 412 nm. SMILES: Clc1ccc(cc1)C1[S]=NOC1O. InChi Code: InChI=1S/C8H6ClNO2S/c9-6-3-1-5(2-4-6)7-8(11)12-10-13-7/h1-4,7-8H. InChi Key: YCOSQMHGRDRAGH-UHFFFAOYSA-N.