CAY10563

S-Nitrosothiols (RSNOs) are a class of molecules that function as exogenous and endogenous nitric oxide (NO) donors. RSNOs found in vivo include proteins such as S-nitrosohemoglobin and S-nitrosoalbumin, as well as low molecular weight species such as S-nitrosoglutathione (GSNO) and S-nitrosocysteine (CysNO). CAY10563 is a member of a new class of S-nitrosothiol species that act as an NO donors under acidic conditions. It decomposes with a half-life of one minute in 0.1 M phosphate buffer, pH 5.0, at 37°C and relaxes phenylephrine-constricted rat aortic strips 59% and 16% at pH 6.0 and 7.4, respectively.Formal Name: 4-trifluoro-4-phenyl-1,3,2-oxathiazolidine-5-one. Synonyms: 4-(p-trifluoromethylphenyl)-1,3,2-Oxathiazolylium-5-olate. Molecular Formula: C9H6F3NO2S. Formula Weight: 249.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH7.2) (1:1): 0.5 mg/ml. lambdamax: 201, 258, 402 nm. SMILES: [O-]C1ON=[S+]C1C2=CC=C(C(F)(F)F)C=C2. InChi Code: InChI=1S/C9H6F3NO2S/c10-9(11,12)6-3-1-5(2-4-6)7-8(14)15-13-16-7/h1-4,7-8H. InChi Key: QDENHOFFQVSMKJ-UHFFFAOYSA-N.