CAY10526

Description: CAY10526 (BTH) is a selective mPGES-1 inhibitor that acts as an inhibitor of the NF-kappaB signaling pathway. Target: Prostaglandin Receptor. Smiles: OC1OC(=O)C(Br)=C1c1cc2ccccc2s1. References: Guerrero, M.D., Aquino, M., Bruno, I., et al. Synthesis and pharmacological evaluation of a selected library of new potential anti-inflammatory agents bearing the gamma-hydroxybutenolide scaffold: a new class of inhibitors of prostanoid production through the selective modulation of microsomal prostaglandin E synthase-1 expression. Journal of Medicinal Chemistry 50, 2176-2184 (2007).