(-)-Catechin Gallate

(-)-Catechin gallate ((-)-CG) is a catechin polyphenol that has been found in green tea extracts with diverse biological activities. It inhibits proliferation of MDA-MB-231 breast cancer cells and reduces VEGF-induced tyrosine phosphorylation of VEGF receptor 2 (VEGFR2) in bovine aortic endothelial cells (BAECs) in a concentration-dependent manner. (-)-CG is a competitive inhibitor of the facilitative glucose transporter GLUT4 (Ki = 90 µM) and inhibits methylglucose uptake by isolated rat adipocytes (IC50 = 50 µM). It is also lytic against T. cruzi amastigotes, with a 50% bactericidal concentration (MBC50) value of 48 pM.Formal Name: 3,4,5-trihydroxy-(2S,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-yl ester, benzoic acid. CAS Number: 130405-40-2. Synonyms: (-)-CG. Molecular Formula: C22H18O10. Formula Weight: 442.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, PBS (pH 7.2): 0.3 mg/ml. lambdamax: 280 nm. SMILES: OC1=CC([C@H]2[C@H](OC(C3=CC(O)=C(O)C(O)=C3)=O)CC4=C(O)C=C(O)C=C4O2)=CC=C1O. InChi Code: InChI=1S/C22H18O10/c23-11-6-14(25)12-8-19(32-22(30)10-4-16(27)20(29)17(28)5-10)21(31-18(12)7-11)9-1-2-13(24)15(26)3-9/h1-7,19,21,23-29H,8H2/t19-,21+/m1/s1. InChi Key: LSHVYAFMTMFKBA-CTNGQTDRSA-N.