Carbenicillin (sodium salt)

Carbenicillin is a broad-spectrum carboxypenicillin antibiotic. It is active against Gram-negative and certain Gram-positive bacteria, including S. pyogenes, S. epidermidis, P. mirabilis, P. vulgaris, E. coli, and P. aeruginosa (MICs = 0.19, 1.56, 1.56, 3.12, 3.12, and 50 µg/ml, respectively). It is also active against penicillinase-producing and non-producing strains of S. aureus (MICs = 1.56 and 12.5 µg/ml, respectively). Carbenicillin is protective against systemic S. pyogenes, P. vulgaris, E. coli, and S. aureus infection in a mouse model of systemic lethal infection with 50% protective dose (PD50) values of 7.8, 224, 19.3, and 34 mg/kg, respectively. It also decreases viable colony counts in the kidney in a rat model of P. vulgaris or E. coli urinary tract infection when administered at a dose of 100 mg/kg. Formulations containing carbenicillin have previously been used in the treatment of upper and lower urinary tract infections and prostatitis.Formal Name: (2S,5R,6R)-6-[(2-carboxy-2-phenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, disodium salt. CAS Number: 4800-94-6. Synonyms: BRL 2064, alpha-Carboxybenzylpenicillin, CP 15,639-2, NSC 111071. Molecular Formula: C17H16N2O6S . 2Na. Formula Weight: 422.4. Purity: >80%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 15 mg/ml, Ethanol: 2.5 mg/ml, PBS (pH 7.2): 5 mg/ml. SMILES: O=C(N[C@@H]1C(N2[C@]1([H])SC(C)(C)[C@@H]2C([O-])=O)=O)C(C([O-])=O)C3=CC=CC=C3.[Na+].[Na+]. InChi Code: InChI=1S/C17H18N2O6S.2Na/c1-17(2)11(16(24)25)19-13(21)10(14(19)26-17)18-12(20)9(15(22)23)8-6-4-3-5-7-8,,/h3-7,9-11,14H,1-2H3,(H,18,20)(H,22,23)(H,24,25),,/q,2*+1/p-2/t9?,10-,11+,14-,,/m1../s1. InChi Key: RTYJTGSCYUUYAL-YCAHSCEMSA-L.