Carbamazepine

Description: Carbamazepine (NSC-169864) is a tricyclic compound chemically related to tricyclic antidepressants (TCA) with anticonvulsant and analgesic properties. Carbamazepine exerts its anticonvulsant activity by reducing polysynaptic responses and blocking post-tetanic potentiation. Its analgesic activity is not understood, however, carbamazepine is commonly used to treat pain associated with trigeminal neuralgia. Target: Autophagy, Mitophagy, Sodium Channel. Smiles: NC(=O)N1C2=CC=CC=C2C=CC2=C1C=CC=C2. References: Willow M, et al. Mol Pharmacol, 1982, 22(3), 627-635.