Capsiate

Capsiate is a non-pungent analog of capsaicin (Cay-92350, Cay-10010743) that has been found in C. annuum and has diverse biological activities. It inhibits Src in, as well as VEGF-induced proliferation of and tube formation by, human umbilical vein endothelial cells (HUVECs) when used at concentrations ranging from 5 to 25 µM. Capsiate activates transient receptor potential vanilloid 1 (TRPV1) in HEK293 cells expressing the human channel (EC50 = 290 nM) and induces licking and biting behaviors, markers of nociception, in mice. Topical application of capsiate reduces antigen-induced increases in ear thickness in a mouse model of passive cutaneous anaphylaxis and decreases epidermal thickness and eosinophil and mast cell infiltration in a mouse model of atopic dermatitis. Capsiate (10 mg/kg) decreases body weight gain and perirenal fat weight, as well as increases oxygen consumption, fat oxidation, and carbohydrate oxidation, in a mouse model of ad libitum feeding-induced weight gain.Formal Name: 8-methyl-6E-nonenoic acid, (4-hydroxy-3-methoxyphenyl)methyl ester. CAS Number: 205687-01-0. Molecular Formula: C18H26O4. Formula Weight: 306.4. Purity: >85% (mixture of isomers). Formulation: (Request formulation change), A liquid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. SMILES: CC(C)/C=C/CCCCC(OCC1=CC(OC)=C(C=C1)O)=O. InChi Code: InChI=1S/C18H26O4/c1-14(2)8-6-4-5-7-9-18(20)22-13-15-10-11-16(19)17(12-15)21-3/h6,8,10-12,14,19H,4-5,7,9,13H2,1-3H3/b8-6+. InChi Key: ZICNYIDDNJYKCP-SOFGYWHQSA-N.