Camostat (mesylate)

Camostat is a protease inhibitor. It inhibits trypsin (Ki = 1 nM), as well as various inflammatory proteases, including plasmin, kallikrein, and thrombin. Camostat (50 µM) inhibits entry of vesicular stomatitis virus (VSV) particles pseudotyped with severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 spike glycoprotein in Calu-3 cells and primary human lung epithelial cells. It reduces the number of SARS-CoV-2 genomic equivalents, a marker of infection, in Calu-3 cells. Camostat inhibits sodium channel function in human airway epithelial cells (IC50 = 50 nM) and enhances mucociliary clearance in sheep. Dietary administration of camostat (1 mg/kg) inhibits the production of TNF-alpha and chemokine (C-C motif) ligand 2 (CCL2) by monocytes, as well as proliferation of pancreatic stellate cells in a rat model of pancreatic fibrosis.Formal Name: 4-[[4-[(aminoiminomethyl)amino]benzoyl]oxy]-benzeneacetic acid, 2-(dimethylamino)-2-oxoethyl ester, monomethanesulfonate. CAS Number: 59721-29-8. Synonyms: Foipan, FOY-305. Molecular Formula: C20H22N4O5 . CH3SO3H. Formula Weight: 494.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml. lambdamax: 264 nm. SMILES: O=C(C1=CC=C(NC(N)=N)C=C1)OC2=CC=C(CC(OCC(N(C)C)=O)=O)C=C2.CS(=O)(O)=O. InChi Code: InChI=1S/C20H22N4O5.CH4O3S/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22,1-5(2,3)4/h3-10H,11-12H2,1-2H3,(H4,21,22,23),1H3,(H,2,3,4). InChi Key: FSEKIHNIDBATFG-UHFFFAOYSA-N.