Calpinactam

Calpinactam is a fungal metabolite originally isolated from M. alpina that has antimycobacterial activity. It is active against M. smegmatis (MIC = 0.78 µg/ml) but not a panel of 13 other bacteria and fungi. Calpinactam increases survival in a silkworm model of M. smegmatis infection (ED50 = 5 µg/larva).Formal Name: D-phenylalanyl-L-leucyl-L-histidyl-D-alpha-glutamyl-N-[(3S)-hexahydro-2-oxo-1H-azepin-3-yl]-D-alloisoleucinamide. CAS Number: 1205538-83-5. Synonyms: FKI-4905. Molecular Formula: C38H57N9O8. Formula Weight: 767.9. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: N[C@@H](C(N[C@H](C(N[C@@H](CC1=CN=CN1)C(N[C@H](CCC(O)=O)C(N[C@@]([C@@H](C)CC)([H])C(N[C@@H]2C(NCCCC2)=O)=O)=O)=O)=O)CC(C)C)=O)CC3=CC=CC=C3. InChi Code: InChI=1S/C38H57N9O8/c1-5-23(4)32(38(55)44-27-13-9-10-16-41-34(27)51)47-35(52)28(14-15-31(48)49)43-37(54)30(19-25-20-40-21-42-25)46-36(53)29(17-22(2)3)45-33(50)26(39)18-24-11-7-6-8-12-24/h6-8,11-12,20-23,26-30,32H,5,9-10,13-19,39H2,1-4H3,(H,40,42)(H,41,51)(H,43,54)(H,44,55)(H,45,50)(H,46,53)(H,47,52)(H,48,49)/t23-,26+,27-,28+,29-,30-,32+/m0/s1. InChi Key: GPDRWULXOJRYOR-XHGFRBTRSA-N. Origin: Fungus/Mortierella alpina.