CA77.1

CA77.1 is an inducer of chaperone-mediated autophagy (CMA). It induces the formation of autophagic lysosomes in NIH3T3 cells expressing a CMA reporter when used at concentrations of 10, 20, and 30 µM. CA77.1 (20 µM) induces autophagic flux in NIH3T3 cells. In vivo, CA77.1 (30 mg/kg) reduces locomotor hyperactivity to control levels and the number of neurons containing pathogenic tau conformations in the hippocampus, amygdala, and piriform cortex in a PS19 transgenic mouse model of Alzheimer's disease.Formal Name: N-[4-(6-chloro-2-quinoxalinyl)phenyl]-acetamide. CAS Number: 2412270-22-3. Molecular Formula: C16H12ClN3O. Formula Weight: 297.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 2 mg/ml, DMSO: 1 mg/ml. lambdamax: 214, 269, 302, 363 nm. SMILES: O=C(C)NC1=CC=C(C2=NC3=CC=C(C=C3N=C2)Cl)C=C1. InChi Code: InChI=1S/C16H12ClN3O/c1-10(21)19-13-5-2-11(3-6-13)16-9-18-15-8-12(17)4-7-14(15)20-16/h2-9H,1H3,(H,19,21). InChi Key: ZQXMPDVGBWOTBY-UHFFFAOYSA-N.