C-82

Description: C-82 is a specific CBP/beta-catenin antagonist. It inhibits the binding between beta-catenin and CBP and increases the binding between beta-catenin and p300. Target: Epigenetic Reader Domain, Wnt/beta-catenin. Smiles: [H][C@]12[C@H](C)N(Cc3cccc4cccnc34)C(=O)[C@H](Cc3ccc(O)cc3)N1C(=O)CN(C)N2C(=O)NCc1ccccc1. References: Osawa Y, et al. Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/beta-Catenin Reduces Liver Fibrosis in Mice. EBioMedicine. 2015 Oct 8,2(11):1751-8.